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ARYL HYDROCARBON HYDROXYLASES
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DeCS
Descriptor
English
:
Aryl Hydrocarbon Hydroxylases
Descriptor
Spanish
:
Hidrocarburo de Aril Hidroxilasas
Descriptor
Portuguese
:
Hidrocarboneto de Aril Hidroxilases
Synonyms
English
:
Microsomal Monooxygenases
Xenobiotic Monooxygenases
Hydroxylases, Aryl Hydrocarbon
Monooxygenases, Microsomal
Monooxygenases, Xenobiotic
Tree Number:
D08.244.453.005
D08.811.682.690.708.170.010
D12.776.422.220.453.010
Definition
English
:
A large group of
cytochrome
P-450 (heme-thiolate) monooxygenases that complex with NAD(P)H-FLAVIN OXIDOREDUCTASE in numerous mixed-function oxidations of aromatic compounds. They catalyze
hydroxylation
of a broad spectrum of
substrates
and are important in the
metabolism
of
steroids
, drugs, and toxins such as
PHENOBARBITAL
,
carcinogens
, and
insecticides.
History Note
English
:
75
Allowable Qualifiers
English
:
AD
administration & dosage
AE
adverse effects
AN
analysis
AI
antagonists & inhibitors
BI
biosynthesis
BL
blood
CF
cerebrospinal fluid
CS
chemical synthesis
CH
chemistry
CL
classification
CT
contraindications
DF
deficiency
DE
drug effects
EC
economics
GE
genetics
HI
history
IM
immunology
IP
isolation & purification
ME
metabolism
PK
pharmacokinetics
PD
pharmacology
PH
physiology
PO
poisoning
RE
radiation effects
SE
secretion
ST
standards
SD
supply & distribution
TU
therapeutic use
TO
toxicity
UL
ultrastructure
UR
urine
Record Number:
23163
Unique Identifier:
D001189
Occurrence in VHL
:
Similar:
DeCS
CID-10
SciELO
LILACS
LIS